Skip to product information
1 of 2

Understand what you're taking

Dr. Stewart's notes on how this formula works and who it's for.

How It Works

After estrogen does its job, the liver converts it into forms the body can clear.*

DIM supports the conversion toward the gentler forms of estrogen.*

Calcium D-glucarate supports the last step, so processed estrogen leaves through the gut instead of being reabsorbed.*

Black pepper extract supports absorption.*

Is This Right for You?

A good fit if you

  • Your NineTwo report recommends it
  • You want support for healthy estrogen balance
  • One capsule morning and evening fits your routine

Talk to your provider first if you

  • Are pregnant, nursing or trying to conceive
  • Have a hormone-sensitive condition, or take hormone therapy or birth control
  • Take prescription medications. DIM and black pepper can change how the liver processes some medications.

Good to know

Take one capsule in the morning and one in the evening.

DIM can darken urine. That's harmless.

How to Take It

Take 1 capsule in the morning and 1 capsule in the evening, or as directed by your healthcare practitioner.

Estro Clear

Estro Clear

Doctor's Formulation Rationale

Your body makes estrogen, uses it, and then has to clear it, and genetics affect how well that last step works. DIM comes from broccoli, cabbage and other cruciferous vegetables, and it supports the liver in processing estrogen into its gentler forms. Calcium D-glucarate supports the final step, helping keep processed estrogen moving out of the body instead of being reabsorbed. A small amount of black pepper extract helps with absorption.

— Kendal Stewart, MD
Regular price $48.67 USD
Regular price Sale price $48.67 USD
Sale Sold out

Checkout With Your HSA/FSA

Maximize your pre-tax HSA/FSA dollars.

  1. Select "Pay another way" or checkout as a guest.

    The checkout payment step, with a cursor clicking 'Pay another way' below a saved card.
  2. Select the "Flex - Pay with HSA/FSA" option.

    The checkout payment options, with 'Flex | Pay with HSA/FSA' selected below the credit card option.
  3. Confirm your eligibility.

    A Flex eligibility check asking 'What condition are you seeking treatment for?', with a field to enter it.
  4. Enter your HSA/FSA card details.

    The Flex HSA/FSA payment form, with card number, expiration, security code, country and ZIP code fields.
Quantity

Why people take it

  • Supports healthy estrogen metabolism*
  • Supports a healthy balance of estrogen metabolites*
  • Supports the body's natural clearance of hormones*
  • Supports healthy liver processing of hormones*
  • Supports hormonal balance*

Supplement Facts & Ingredients

Serving Size: Serving Size: 1 Capsule Servings Per Container: 120
Active Ingredient Amount Per Serving % Daily Value
Calcium (as Calcium D-Glucarate) 12 mg <1%
Calcium D-Glucarate 100 mg ††
Diindolylmethane 100 mg ††
Black Pepper Fruit Extract (95% Piperine) 1 mg *
Daily Value (DV) not established. Other Ingredients: Microcrystalline cellulose, hypromellose (capsule), silicon dioxide, ascorbyl palmitate. Distributed by NineTwo . (512) 216-5016 11719 Bee Cave Road Ste. 204, Austin, TX 78738 Manufactured in a cGMP facility.
View full details
GENETIC PANEL MATCH · SLEEP, MOOD & COGNITION ANALYSIS

Your genes may already be pointing you here

Estro Clear is one of the formulas our Sleep, Mood and Cognition Analysis can recommend. The report looks at the genes that shape how your body clears hormones and other messengers, then shows where your hormone clearance may need support.

COMT

Clearing estrogen with methyl groups

DIM and calcium D-glucarate support the other clearance steps.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Board–Certified MD Founded
Board–Certified MD Founded
30+ years treating complex chronic patients
CLIA–Certified US Lab
CLIA–Certified US Lab
High-depth genetic sequencing precision
Active Methylated Co–Factors
Active Methylated Co–Factors
Bioavailable nutrients that bypass SNP blocks
100% Third–Party Batch Tested
100% Third–Party Batch Tested
Verified purity, zero fillers, cGMP certified

Frequently Asked Questions

Personalized wellness through genetic testing, education, and targeted supplementation.
Our advanced panel tests key enzymes including MTHFR and COMT to uncover pathway bottlenecks and optimize energy production.
Evaluates hepatic phase I and phase II clearance genes to optimize endogenous glutathione pathways and cellular detox.
A non-invasive cheek swab collected at home is analyzed at our CLIA-certified laboratory with results available in 2–3 weeks.
Comprehensive clinical panels engineered specifically to guide targeted nutrition, co-factor dosing, and bio-individual lifestyle protocols.
Yes, our bioavailable co-factor formulas are crafted specifically to bypass the exact SNP blocks identified in your panel.