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Understand what you're taking

Dr. Stewart's notes on how this formula works and who it's for.

How It Works

Histamine comes in with foods like aged cheese, wine, fermented foods, cured meats and leftovers.*

In the gut, the DAO enzyme breaks that histamine down. Your AOC1 gene affects how much DAO you make.*

Porcine kidney is a natural source of DAO, so the formula supplies the enzyme alongside your meal.*

Vitamin C and stinging nettle support a balanced histamine response, and bromelain supports digestion.*

Is This Right for You?

A good fit if you

  • Your NineTwo GI report shows decreased function of your histamine genes (AOC1, HNMT)
  • Histamine-rich foods and drinks don't sit well with you
  • You want something to take before specific meals

Talk to your provider first if you

  • Have a diagnosed food allergy. This product isn't designed for food allergies.
  • Take blood thinners. Bromelain can affect clotting.
  • Are allergic to pineapple (bromelain comes from pineapple)
  • Are pregnant or nursing

Good to know

Contains a pork-derived ingredient (porcine kidney), the natural source of DAO.

For a specific meal, take it no more than 15 minutes before eating.

How to Take It

Take 1 to 2 capsules no more than 15 minutes before histamine-rich foods or drinks. For daily maintenance, take 2 capsules in the morning and 2 capsules in the evening.

GI Histamine Neutralizer

GI Histamine Neutralizer

Doctor's Formulation Rationale

Some genetic mutations decrease the production of enzymes that break down histamine, especially DAO, which handles the histamine that comes in with food. Aged cheese, wine, cured meats and leftovers all carry a lot of it, and when DAO can't keep up, the gut and immune system feel it. Porcine kidney is a natural source of DAO, so this formula supplies the enzyme directly. I added vitamin C and stinging nettle to support a balanced histamine response, plus bromelain, NAC and alpha lipoic acid for digestive and antioxidant support. Take it right before a histamine-rich meal, or morning and evening for daily support.

— Kendal Stewart, MD
$48.67 USD
$48.67 USD
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Why people take it

  • Supports the breakdown of histamine from food*
  • Supports a healthy histamine response*
  • Supports digestive comfort after histamine-rich meals*
  • Supports healthy immune balance*
  • Provides antioxidant support*

Supplement Facts & Ingredients

Serving Size: Serving Size: 2 Capsules, Servings Per Container: 30
Active Ingredient Amount Per Serving % Daily Value
Vitamin C (Ascorbic Acid) 200 mg 222%
Porcine Kidney Powder 300 mg ††
N-Acetyl Cysteine 100 mg ††
Alpha Lipoic Acid 100 mg ††
Bromelain 100 mg (7 GDU) ††
Stinging Nettle Root 4:1 Extract (Urtica dioica) (Equivalent to 200 mg of Root) 50 mg ††
†† Daily Value not established.
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GENETIC PANEL MATCH · GASTROINTESTINAL ANALYSIS

Your genes may already be pointing you here

GI Histamine Neutralizer is one of the formulas our Gastrointestinal Analysis can recommend. The report looks at the genes that shape how you break down histamine from food, then shows where your gut may need support.

View DNA Test Panel ($169)

AOC1

Makes DAO, which breaks down histamine from food

Porcine kidney supplies DAO directly.

HNMT

Breaking down histamine inside your cells

Vitamin C and nettle support a balanced histamine response.

Your genes don't diagnose anything. They show tendencies, and your report turns them into a plan.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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30+ years treating complex chronic patients
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Bioavailable nutrients that bypass SNP blocks
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Frequently Asked Questions

Personalized wellness through genetic testing, education, and targeted supplementation.
Our advanced panel tests key enzymes including MTHFR and COMT to uncover pathway bottlenecks and optimize energy production.
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