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Understand what you're taking

Dr. Stewart's notes on how this formula works and who it's for.

How It Works

Folate is the main source of the methyl groups your body uses for methylation, the process behind energy, neurotransmitters, detox and DNA repair.*

L-5-methylfolate is folate in its active form. It's ready to use without going through the MTHFR conversion step.*

Folinic acid is a second active form that enters the folate cycle further upstream, where it also supports the steps that build and repair DNA.*

Riboflavin (B2) is the helper the MTHFR enzyme needs to work. Niacinamide (B3) supports the enzymes that keep folate moving through the cycle.*

Is This Right for You?

A good fit if you

  • Your NineTwo Methylation report shows changes in folate transport or conversion genes (FOLR1/2, MTHFS, MTHFR)
  • You need more folate support than Methyl B Complex Pro provides
  • You prefer capsules

Talk to your provider first if you

  • Take methotrexate, seizure medications, or other prescriptions that folate can affect
  • Have a history of mood conditions or take antidepressants
  • Have significant inflammation or an active infection right now
  • Already take another folate or methylfolate product

Good to know

Methylfolate is also used by your immune system. Starting it while you have significant inflammation can make that inflammation worse.

Some people are sensitive to higher doses of methylfolate and do better starting with a smaller dose, then building up.

Riboflavin can turn urine bright yellow. That's normal and harmless.

How to Take It

Take 1 capsule twice daily, or as directed by your healthcare practitioner.

Methylfolate/Folinic Pro

Methylfolate/Folinic Pro

Doctor's Formulation Rationale

This is my higher-dose activated folate formula. It combines two forms of bioactive folate: L-5-methylfolate and folinic acid. Taking both forms matters for different cellular activities. I added riboflavin and niacinamide to support the enzymes that keep the folate cycle turning. I use this formula when a report shows a more severe methylation weakness.

— Kendal Stewart, MD
$44.03 USD
$44.03 USD
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Why people take it

  • Supports healthy methylation*
  • Provides two active forms of folate, with no conversion from folic acid needed*
  • Helps maintain healthy homocysteine levels*
  • Supports cellular energy production*
  • Supports healthy nervous system function*

Supplement Facts & Ingredients

Serving Size: Serving Size: 1, Tablet Servings Per Container: 120
Active Ingredient Amount Per Serving % Daily Value
Riboflavin (Vitamin B2) (as Riboflavin-5-Phosphate) 30 mg 2308%
Niacin (as Niacinamide) 125 mg NE 781%
Folate (from L-5-Methyltetrahydrofolate Calcium Salt and Folinic Acid Calcium Salt) 9770 mcg DFE 2443%
Other Ingredients: Hypromellose (Capsule), Rice Flour, Ascorbyl Palmitate and Silicon Dioxide. Distributed by NineTwo • (512) 216-5016 11719 Bee Cave Road Ste. 204, Austin, TX 78738 Manufactured in a cGMP facility.
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GENETIC PANEL MATCH · METHYLATION AND CELLULAR ENERGY ANALYSIS

Your genes may already be pointing you here

Methylfolate/Folinic Pro is one of the formulas our Methylation and Cellular Energy Analysis can recommend. The report looks at the genes that shape how you carry folate into your cells and convert it, then shows where your methylation may need support.

View DNA Test Panel ($169)

FOLR1

Carrying folate into your cells

The formula supplies a higher dose of active folate to work with.

MTHFR

Converting folate into active 5-MTHF

L-5-methylfolate is already converted, so this step is skipped.

MTHFS

Moving folinic acid through the folate cycle

The formula also supplies L-5-methylfolate, which doesn't depend on this step.

Your genes don't diagnose anything. They show tendencies, and your report turns them into a plan.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Board–Certified MD Founded
Board–Certified MD Founded
30+ years treating complex chronic patients
CLIA–Certified US Lab
CLIA–Certified US Lab
High-depth genetic sequencing precision
Active Methylated Co–Factors
Active Methylated Co–Factors
Bioavailable nutrients that bypass SNP blocks
100% Third–Party Batch Tested
100% Third–Party Batch Tested
Verified purity, zero fillers, cGMP certified

Frequently Asked Questions

Personalized wellness through genetic testing, education, and targeted supplementation.
Our advanced panel tests key enzymes including MTHFR and COMT to uncover pathway bottlenecks and optimize energy production.
Evaluates hepatic phase I and phase II clearance genes to optimize endogenous glutathione pathways and cellular detox.
A non-invasive cheek swab collected at home is analyzed at our CLIA-certified laboratory with results available in 2–3 weeks.
Comprehensive clinical panels engineered specifically to guide targeted nutrition, co-factor dosing, and bio-individual lifestyle protocols.
Yes, our bioavailable co-factor formulas are crafted specifically to bypass the exact SNP blocks identified in your panel.