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Understand what you're taking

Dr. Stewart's notes on how this formula works and who it's for.

How It Works

Methylation is your body passing a tiny chemical tag, called a methyl group, from one molecule to another. It happens constantly in every cell and helps your body make energy, build neurotransmitters, process hormones and clear toxins.*

Step 1, Folate

Active folate supplies the tag

It's delivered as 5-MTHF, so it doesn't need the MTHFR enzyme to convert it first.*

Step 2, B12

B12 hands the tag off

Turning homocysteine into methionine. Without B12, folate gets stuck and can't do its job.*

Step 3, B6

B6 keeps the cycle

Clear by routing leftover homocysteine toward glutathione, a key antioxidant.*

Together, the three ingredients cover each handoff in the cycle instead of supporting just one.

Is This Right for You?

A good fit if you

  • Your NineTwo report identifies an issue in your methylation, folate or B12 pathways
  • You want B vitamins in their active forms instead of folic acid or cyanocobalamin
  • You prefer a tablet that dissolves in your mouth over swallowing capsules

Talk to your provider first if you

  • Are pregnant, nursing or planning a pregnancy, or want to give it to a child
  • Take methotrexate, seizure medications, or other prescriptions that folate can affect
  • Have a history of mood conditions
  • Have significant inflammation or an active infection right now
  • Already take another methylfolate or B12 product, including Methylfolate/Folinic Pro or Topical Methyl B Complex

Good to know

This is a high-potency formula. Each tablet supplies well above the Daily Value of folate and B12, for targeted support.

Some people are sensitive to methylated B vitamins and do better starting with half a tablet.

If your genes clear dopamine more slowly (COMT), high-dose methylated B12 can leave you feeling jittery or anxious. If that happens, cut back.

Methylfolate is also used by your immune system. Starting it while you have significant inflammation can make that inflammation worse.

Take it earlier in the day. Some people find active B vitamins energizing.

The tablet is sweetened with sorbitol and mannitol, which can upset the stomach in sensitive people.

How to Take It

Place 1 tablet in the mouth twice daily, or as directed by your healthcare practitioner. Allow 1–3 minutes for the tablet to dissolve, then swallow.

Methyl B Complex Pro

Methyl B Complex Pro

Doctor's Formulation Rationale

Methylation runs on B vitamins working as a team, and a shortfall in any one of them slows the whole cycle. I utilized folate that is already in its active form and paired it with two forms of B12, including the form your mitochondria use for energy.

— Kendal Stewart, MD
Regular price $63.09 USD
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Why people take it

  • Supports healthy methylation, the process behind energy, detox and nervous system function*
  • Helps maintain healthy homocysteine levels*
  • Supports cellular energy production*
  • Supports healthy brain and nervous system function*
  • Delivers folate in its active form, with no conversion step needed*

Supplement Facts & Ingredients

Serving Size: Serving Size: 1, Tablet Servings Per Container: 120
Active Ingredient Amount Per Serving % Daily Value
Vitamin B6 (as Pyridoxal-5-Phosphate) 2 mg 118%
Folate (as L-Methylfolate Calcium & Quatrefolic®†† L-Methylfolate Glucosamine) 5440 mcg DFE 1360%
Vitamin B12 (as Methylcobalamin and Hydroxycobalamin) 7000 mcg 291667%
Other ingredients: Sorbitol, mannitol, croscarmellose sodium, stearic acid, blue spirulina (color), natural flavors, ascorbyl palmitate, silicon dioxide. †† Quatrefolic® is a registered trademark of Gnosis S.p.A. Does not contain gluten, dairy, soy protein, or GMOs.
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GENETIC PANEL MATCH · METHYLATION AND CELLULAR ENERGY ANALYSIS

Your genes may already be pointing you here

Methyl B Complex Pro is one of the formulas our Methylation and Cellular Energy Analysis can recommend. The report looks at the genes that shape how you convert folate and deliver B12 to your cells, then shows where your methylation may need support.

MTHFR

Converting folate into active 5-MTHF

The formula supplies 5-MTHF directly, skipping the conversion step.

TCN1 / TCN2

Carrying B12 through the blood and into cells

Two forms of B12 help keep a steady supply available.

MTR / MTRR

Using B12 to turn homocysteine into methionine

Methylcobalamin is the B12 form this step uses.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Board–Certified MD Founded
Board–Certified MD Founded
30+ years treating complex chronic patients
CLIA–Certified US Lab
CLIA–Certified US Lab
High-depth genetic sequencing precision
Active Methylated Co–Factors
Active Methylated Co–Factors
Bioavailable nutrients that bypass SNP blocks
100% Third–Party Batch Tested
100% Third–Party Batch Tested
Verified purity, zero fillers, cGMP certified
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A
Alex

"The sample report and protocol gave me and my practitioner the exact clinical roadmap we needed."

Frequently Asked Questions

Personalized wellness through genetic testing, education, and targeted supplementation.
Our advanced panel tests key enzymes including MTHFR and COMT to uncover pathway bottlenecks and optimize energy production.
Evaluates hepatic phase I and phase II clearance genes to optimize endogenous glutathione pathways and cellular detox.
A non-invasive cheek swab collected at home is analyzed at our CLIA-certified laboratory with results available in 2–3 weeks.
Comprehensive clinical panels engineered specifically to guide targeted nutrition, co-factor dosing, and bio-individual lifestyle protocols.
Yes, our bioavailable co-factor formulas are crafted specifically to bypass the exact SNP blocks identified in your panel.