Skip to product information
1 of 2

Understand what you're taking

Dr. Stewart's notes on how this formula works and who it's for.

How It Works

Methylation depends on active folate, B12 and B6 working together. It's the process behind energy, neurotransmitters, detox and DNA repair.

Some people can't take methylated B vitamins by mouth: small children who can't swallow capsules, and adults whose stomachs don't tolerate them. This lotion is another way to use them.

The vitamins are absorbed through the skin.

Is This Right for You?

A good fit if you

  • Your NineTwo Methylation analysis recommends Methyl B Complex Pro or Topical Methyl B Complex, and swallowing pills is a problem
  • You're choosing for a child (see the under-3 guidance below)
  • Oral methylated vitamins upset your stomach

Talk to your provider first if you

  • Want to use it on a child under 3
  • Are pregnant, nursing or planning a pregnancy
  • Take methotrexate, seizure medications, or other prescriptions that folate can affect
  • Have a skin condition where you'd apply it
  • Already take another methylfolate or B12 product, including Methyl B Complex Pro

Good to know

Apply it to skin without hair. For children, the back works best.

Don't apply it to broken skin. If you notice any skin reaction, stop using it.

For external use only.

Store it between 65°F and 80°F, away from direct sunlight and heat. Don't freeze it.

How to Take It

Apply 2 pumps daily: 1 pump in the morning and 1 pump 2 hours before bedtime, on an area of skin without hair. Do not apply to broken skin. For children, the back works best. For children under 3, consult your healthcare provider.

Topical Methyl B Complex

Topical Methyl B Complex

Doctor's Formulation Rationale

I developed this lotion for patients who couldn't take methylated B vitamins by mouth: small children who won't swallow a capsule, and adults whose stomachs don't tolerate them. It carries the same forms of active B vitamins I use in my oral methylation formulas: L-5-methylfolate, folinic acid, both active forms of B12, and B6 in its active form. I also added vitamins D3 and K1. One pump in the morning and one before bed keeps it simple for families.

— Kendal Stewart, MD
Regular price $64.63 USD
Regular price Sale price $64.63 USD
Sale Sold out
Quantity

Why people take it

  • Contains active folate, folinic acid, two forms of B12 and active B6 in one lotion
  • A no-swallow option for children and anyone who can't take methylated vitamins by mouth
  • A simple routine: one pump in the morning and one before bed
  • Free of gluten, dairy, soy protein and GMOs
  • Supports healthy methylation*

Supplement Facts & Ingredients

Serving Size: WARNING: Safety of this product has not been determined.
Active Ingredient Amount Per Serving % Daily Value
Water (Aqua) †† ††
Propanediol, Vitamin E (Tocopherol) †† ††
Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7 †† ††
Caprylic/ Capric Triglycerides †† ††
Urea †† ††
Glycerin †† ††
Cetearyl Alcohol (and) Ceteareth-20 †† ††
Phenoxyethanol †† ††
Coconut Oil (Cocos Nucifera Oil) †† ††
Calcium L-5-Methyltetrahydrofolate †† ††
Folate (as calcium folinate) †† ††
Citric Acid †† ††
Vitamin B6 (pyridoxal-5-phosphate) †† ††
Gardenia Fruit Extract (Gardenia Jasminoides Fruit Extract) †† ††
Aloe Leaf (Aloe Barbadensis Leaf) †† ††
Orange Peel Extract (Citrus Sinensis Peel Extract) †† ††
Grapefruit Peel Oil (Citrus Paradisi Peel Oil) †† ††
Vitamin D3 (Cholecalciferol) †† ††
Rose Hips Fruit Extract (Rosa Canina Fruit Extract) †† ††
Vitamin B12 (methylcobalamin) †† ††
Vitamin B12 (hydroxycobalamin) †† ††
MSM (methylsulfonylmethane) †† ††
Sodium Hyaluronate †† ††
Panthenol †† ††
Folate (as (6s)-5-methyltetrahydrofolate, glucosamine salt) †† ††
Vitamin K1. †† ††
Distributed by NineTwo • (512) 216-5016 11719 Bee Cave Road Ste. 204, Austin, TX 78738 Manufactured in a cGMP facility. STORAGE: Store away from light and heat. Do not store in direct sunlight or temperatures above 90°F. Do not freeze. Product is best when stored between 65°F and 80°F CAUTION: For external use only. Keep out of reach of children.
View full details
GENETIC PANEL MATCH · METHYLATION AND CELLULAR ENERGY ANALYSIS

Your genes may already be pointing you here

Topical Methyl B Complex is one of the formulas our Methylation and Cellular Energy Analysis can recommend. The report looks at the genes that shape how you carry folate into your cells and convert it, then shows where your methylation may need support.

FOLR1

Carrying folate into your cells

The lotion supplies active folate in two forms.

MTHFR

Converting folate into active 5-MTHF

L-5-methylfolate is already converted, so this step is skipped.

MTHFS

Moving folinic acid through the folate cycle

The lotion also supplies L-5-methylfolate, which doesn't depend on this step.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Board–Certified MD Founded
Board–Certified MD Founded
30+ years treating complex chronic patients
CLIA–Certified US Lab
CLIA–Certified US Lab
High-depth genetic sequencing precision
Active Methylated Co–Factors
Active Methylated Co–Factors
Bioavailable nutrients that bypass SNP blocks
100% Third–Party Batch Tested
100% Third–Party Batch Tested
Verified purity, zero fillers, cGMP certified

Frequently Asked Questions

Personalized wellness through genetic testing, education, and targeted supplementation.
Our advanced panel tests key enzymes including MTHFR and COMT to uncover pathway bottlenecks and optimize energy production.
Evaluates hepatic phase I and phase II clearance genes to optimize endogenous glutathione pathways and cellular detox.
A non-invasive cheek swab collected at home is analyzed at our CLIA-certified laboratory with results available in 2–3 weeks.
Comprehensive clinical panels engineered specifically to guide targeted nutrition, co-factor dosing, and bio-individual lifestyle protocols.
Yes, our bioavailable co-factor formulas are crafted specifically to bypass the exact SNP blocks identified in your panel.